Table 1.
Selected DEPs in LPS+Nbn relative to LPS involved in inflammatory response, TNFα-NFκB pathway and metabolic pathway.
| Category | Gene name | UniProt ID | Protein name | Log2 FC | Regulation |
|---|---|---|---|---|---|
| Inflammatory response | Znfx1 | Q8R151 | NFX1-type zinc finger-containing protein 1 | -0.988 | Down |
| Epsti1 | Q8VDI1 | Epithelial-stromal interaction protein 1 | -1.246 | Down | |
| Lcp2 | Q60787 | Lymphocyte cytosolic protein 2 | -1.192 | Down | |
| Tnfaip2 | Q61333 | Tumor necrosis factor alpha-induced protein 2 | -1.515 | Down | |
| Isg20 | Q9JL16 | Interferon-stimulated gene 20 kDa protein | -1.380 | Down | |
| Pml | Q60953 | Protein PML | -1.514 | Down | |
| Ifih1 | Q8R5F7 | Interferon-induced helicase C domain-containing protein 1 | -1.914 | Down | |
| Ube2L6 | Q9QZU9 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | -0.956 | Down | |
| Rsad2 | Q8CBB9 | Radical S-adenosyl methionine domain-containing protein 2 | -4.611 | Down | |
| Ptgs2 | Q05769 | Prostaglandin G/H synthase 2 | -2.469 | Down | |
| Cdkn1A | P39689 | Cyclin-dependent kinase inhibitor 1 | -0.908 | Down | |
| Trafd1 | Q3UDK1 | TRAF-type zinc finger domain-containing protein 1 | -2.165 | Down | |
| Icam1 | P13597 | Intercellular adhesion molecule 1 | -1.082 | Down | |
| Sp110 | Q8BVK9 | Sp110 nuclear body protein | -0.603 | Down | |
| Peli1 | Q8C669 | E3 ubiquitin-protein ligase pellino homolog 1 | -2.031 | Down | |
| Parp14 | Q2EMV9 | Poly [ADP-ribose] polymerase 14 | -0.827 | Down | |
| Cd40 | P27512 | Tumor necrosis factor receptor superfamily member 5 | -1.456 | Down | |
| Ccl7 | Q03366 | C-C motif chemokine 7 | -2.714 | Down | |
| Helz2 | E9QAM5 | Helicase with zinc finger domain 2 | -0.868 | Down | |
| Cmpk2 | Q3U5Q7 | UMP-CMP kinase 2, mitochondrial | -2.141 | Down | |
| Isg15 | Q64339 | Ubiquitin-like protein ISG15 | -1.339 | Down | |
| Cxcl10 | P17515 | C-X-C motif chemokine 10 | -5.978 | Down | |
| Ccl2 | P10148 | C-C motif chemokine 2 | -4.226 | Down | |
| TNFα-NFκB pathway | Junb | P09450 | Transcription factor jun-B | -1.937 | Down |
| Plek | Q9JHK5 | Pleckstrin | -0.696 | Down | |
| Tnfaip2 | Q61333 | Tumor necrosis factor alpha-induced protein 2 | -1.515 | Down | |
| Ifih1 | Q8R5F7 | Interferon-induced helicase C domain-containing protein 1 | -1.914 | Down | |
| Ptgs2 | Q05769 | Prostaglandin G/H synthase 2 | -2.469 | Down | |
| Cebpd | Q00322 | CCAAT/enhancer-binding protein delta | -1.263 | Down | |
| Cdkn1A | P39689 | Cyclin-dependent kinase inhibitor 1 | -0.908 | Down | |
| Icam1 | P13597 | Intercellular adhesion molecule 1 | -1.082 | Down | |
| Cebpb | P28033 | CCAAT/enhancer-binding protein beta | -1.082 | Down | |
| Cxcl10 | P17515 | C-X-C motif chemokine 10 | -5.978 | Down | |
| Ccl2 | P10148 | C-C motif chemokine 2 | -4.226 | Down | |
| Sqstm1 | Q64337 | Sequestosome-1 | -1.309 | Down | |
| Metabolic pathway | Cmpk2 | Q3U5Q7 | UMP-CMP kinase 2, mitochondrial | -2.141 | Down |
| Dck | P43346 | Deoxycytidine kinase | -0.704 | Down | |
| Hmox1 | P14901 | Heme oxygenase 1 | -0.404 | Down | |
| Irg1 | P54987 | Cis-aconitate decarboxylase | -1.669 | Down | |
| Nos2 | P29477 | Nitric oxide synthase, inducible | -2.830 | Down | |
| Ppat | Q8CIH9 | Amidophosphoribosyltransferase | 2.506 | Up | |
| Cpt2 | P52825 | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.134 | Up | |
| Dnmt3A | O88508 | DNA (cytosine-5)-methyltransferase 3A | 1.718 | Up | |
| Cad | B2RQC6 | Glutamine-dependent carbamoyl-phosphate synthase | 0.895 | Up | |
| Ndufa9 | Q9DC69 | NADH dehydrogenase 1 alpha subcomplex subunit 9 | 0.767 | Up | |
| Polr2B | Q8CFI7 | DNA-directed RNA polymerase II subunit RPB2 | 0.652 | Up |