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. 2023 May 26;42(6):112621. doi: 10.1016/j.celrep.2023.112621

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The E406W mutation dampens ACE2 binding severely

(A–C) Biolayer interferometry binding analysis of monomeric human ACE2 to immobilized Wuhan-Hu-1 (A), Alpha (N501Y, B), or E406W (C) RBDs.

(D) Mutation effects on avidity for dimeric human ACE2 as measured by yeast surface display¹⁹ for the E406W mutation and RBD mutations found in human-derived SARS-CoV-2 isolates deposited in GISAID as of September 27, 2021, across increasing frequency thresholds.