Scaffold Implantation |
Female Sprague Dawley Rats |
FTY720 PLGA Microspheres |
Burst: N/A |
Das et al. (2014a)
|
Long Term: 70% over 4 weeks |
Sprague Dawley Rats |
FTY720 loaded MGB-PLGA nanofiber scaffold |
Burst: ∼10% on day 1 |
Li et al. (2019)
|
Long Term: 85% over 8 weeks |
Rats |
FTY720 and BMSC loaded silk fibrin and gelatin 3D printed scaffold |
Burst: 37.95% on day 1 |
Yang et al. (2022)
|
Long Term: 66.31% over 2 weeks |
Male Sprague Dawley Rats |
50:50 PLGA Microsphere or 85:15 PLGA Microspheres |
Burst: 85:15%–25% of FTY in 20 min; 50:50–N/A |
Das et al. (2014b)
|
Long Term: N/A |
C57BL/6 Mice |
FTY loaded PLGA/PCL nanofiber scaffold |
Burst: 96% on day 1 |
San Emeterio et al. (2021)
|
Long Term: 97% at 75 h |
C57BL/6 Mice |
FTY720 PLGA/PCL nanofiber scaffold |
Burst: N/A |
Amanso et al. (2021)
|
C57BL/6 Mice |
FTY720 PLGA/PCL nanofiber scaffold |
Long Term: Near 100% release at 80 h |
Ballestas et al. (2019)
|
C57BL/6 Mice, NG2–DsRed mice, CX3CR1–eGFP mice |
FTY720 PLAGA/PCL nanofiber scaffold |
|
Awojoodu et al. (2013)
|
Drug/Polymer Coated Allograft |
Female Sprague Dawley Rats |
FTY720 coated bone allograft |
Burst: N/A |
Huang et al. (2012)
|
Long Term: 53% over 5 days |
“Film” Implantation |
Male C57BL/6 Mice |
FTY720-loaded Dichloromethane film |
|
San Emeterio et al. (2017)
|
Hydrogel Implantation |
Male C57BL/6 mice |
Heparin and PEG-DA hydrogel |
Burst: N/A |
Ogle et al. (2017)
|
Long Term: 87.2% in 7 days |