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. 2023 May 12;14:1148932. doi: 10.3389/fphys.2023.1148932

TABLE 1.

A review of the delivery mechanisms, animal models, biomaterial and release kinetics of studies pertaining to the administration and delivery of FTY720 into an animal model.

Delivery mechanism Animal model Composition Release kinetics Citation
Scaffold Implantation Female Sprague Dawley Rats FTY720 PLGA Microspheres Burst: N/A Das et al. (2014a)
Long Term: 70% over 4 weeks
Sprague Dawley Rats FTY720 loaded MGB-PLGA nanofiber scaffold Burst: ∼10% on day 1 Li et al. (2019)
Long Term: 85% over 8 weeks
Rats FTY720 and BMSC loaded silk fibrin and gelatin 3D printed scaffold Burst: 37.95% on day 1 Yang et al. (2022)
Long Term: 66.31% over 2 weeks
Male Sprague Dawley Rats 50:50 PLGA Microsphere or 85:15 PLGA Microspheres Burst: 85:15%–25% of FTY in 20 min; 50:50–N/A Das et al. (2014b)
Long Term: N/A
C57BL/6 Mice FTY loaded PLGA/PCL nanofiber scaffold Burst: 96% on day 1 San Emeterio et al. (2021)
Long Term: 97% at 75 h
C57BL/6 Mice FTY720 PLGA/PCL nanofiber scaffold Burst: N/A Amanso et al. (2021)
C57BL/6 Mice FTY720 PLGA/PCL nanofiber scaffold Long Term: Near 100% release at 80 h Ballestas et al. (2019)
C57BL/6 Mice, NG2–DsRed mice, CX3CR1–eGFP mice FTY720 PLAGA/PCL nanofiber scaffold Awojoodu et al. (2013)
Drug/Polymer Coated Allograft Female Sprague Dawley Rats FTY720 coated bone allograft Burst: N/A Huang et al. (2012)
Long Term: 53% over 5 days
“Film” Implantation Male C57BL/6 Mice FTY720-loaded Dichloromethane film San Emeterio et al. (2017)
Hydrogel Implantation Male C57BL/6 mice Heparin and PEG-DA hydrogel Burst: N/A Ogle et al. (2017)
Long Term: 87.2% in 7 days