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. 2023 May 12;17:1170996. doi: 10.3389/fnins.2023.1170996

Figure 2.

Figure 2

Methods for the discovery of ALS pathogenic genes and their association with other neurological diseases. Each circle indicates one disease and its name is presented beside it in red color. There are 15 genes associated with both ALS and FTD; 1 gene associated with ALS, ataxia, and FTD; 1 gene associated with both ALS and SCA2; 1 gene associated with both ALS and HSP; 1 gene associated with ALS, HSP, and CMT2. ALS, amyotrophic lateral sclerosis; GWAS, genome-wide association study; WGS, whole-genome sequencing; WES, whole-exome sequencing; NGS, next-generation sequencing; RP-PCR, repeat-primed polymerase chain reaction; SNP, single nucleotide polymorphism.