TABLE 1.
Analysis of therapeutic combinations of AOP-RANTES and Met-SDF-1β at IC95 and IC99 in PBMC
Well no. | Drug condition | Viral isolate(s) | IC95 drug exposure
|
IC99 drug exposure
|
||
---|---|---|---|---|---|---|
HIV-1 p24 production (ng/ml) | % Inhibition | HIV-1 p24 production (ng/ml) | % Inhibition | |||
1 | Infected control | DK | 60.2 | 87.9 | ||
2 | 60.5 | 102.0 | ||||
3 | Infected control | RM | 70 | 63.4 | ||
4 | 60 | 51.3 | ||||
5 | Infected control | DK + RM | 136 | 120.4 | ||
6 | 130.4 | 115.1 | ||||
7 | AOP-RANTES | RM | 6 | 91 | 15.5 | 75 |
8 | 7 | 89 | 12.2 | 82 | ||
9 | Met-SDF-1β | DK | 0.4 | 99 | 3.7 | 99 |
10 | 0.4 | 99 | 6.3 | 99 | ||
11 | AOP-RANTES + Met-SDF-1β | DK + RM | 6.2 | 95 | 8.7 | 99 |
12 | 6 | 95 | 8.6 | 99 | ||
13 | AOP-RANTES | DK + RM | 83.3 | 37 | 66.5 | 46 |
14 | 97.7 | 27 | 23.9 | 85 | ||
15 | Met-SDF-1β | DK + RM | 69.4 | 48 | 63.2 | 49 |
16 | 75.5 | 43 | 30.6 | 79 |