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. 2000 Oct;74(19):9328–9332. doi: 10.1128/jvi.74.19.9328-9332.2000

TABLE 1.

Analysis of therapeutic combinations of AOP-RANTES and Met-SDF-1β at IC95 and IC99 in PBMC

Well no. Drug condition Viral isolate(s) IC95 drug exposure
IC99 drug exposure
HIV-1 p24 production (ng/ml) % Inhibition HIV-1 p24 production (ng/ml) % Inhibition
1 Infected control DK 60.2 87.9
2 60.5 102.0
3 Infected control RM 70 63.4
4 60 51.3
5 Infected control DK + RM 136 120.4
6 130.4 115.1
7 AOP-RANTES RM 6 91 15.5 75
8 7 89 12.2 82
9 Met-SDF-1β DK 0.4 99 3.7 99
10 0.4 99 6.3 99
11 AOP-RANTES + Met-SDF-1β DK + RM 6.2 95 8.7 99
12 6 95 8.6 99
13 AOP-RANTES DK + RM 83.3 37 66.5 46
14 97.7 27 23.9 85
15 Met-SDF-1β DK + RM 69.4 48 63.2 49
16 75.5 43 30.6 79