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. 2023 May 12;13:1188371. doi: 10.3389/fonc.2023.1188371

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Copyright © 2023 Zhu, He, Cao and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The inhibitors related to TSC2-mTOR axis active in preclinical and clinical trials. Black arrows indicate stimulation and red blocked arrows indicate inhibition. Abbreviations: HER2, human epidermal growth factor receptor 2; PI3K, phosphatidylinositol 3-kinase; AKT, protein kinase B; TSC1/2, tuberous sclerosis protein complex 1 and 2; mTORC1, mechanistic target of rapamycin complex 1; AMPK, AMP-activated protein kinase; CDK4, cyclin D-dependent kinase 4.