Table 1.
The Fold change in the expression of the miRs that showed opposite regulation in urinary exosomes (uE) and renal biopsies from T2DM patients with diabetic nephropathy (DN), relative to respective controls.
| Urinary exosomes (uE) |
Renal biopsy tissues | ||
|---|---|---|---|
| S.No | Transcript ID | Fold change (DN vs. DC) |
Fold change (DN vs. Cnt.) |
| 1 | hsa-miR-103a-3p | 4.62 | -5.36 |
| 2 | hsa-miR-151a-5p | 3.25 | -4.6 |
| 3 | hsa-miR-191-5p | 8.51 | -6.35 |
| 4 | hsa-miR-1972 | 6.89 | -3.18 |
| 5 | hsa-miR-22-3p | 3.78 | -32.05 |
| 6 | hsa-miR-24-3p | 5.87 | -7.06 |
| 7 | hsa-miR-26a-5p | 10.09 | -8.1 |
| 8 | hsa-miR-30d-5p | 2.32 | -10.37 |
| 9 | hsa-miR-361-5p | 2.77 | -4.1 |
| 10 | hsa-miR-378a-3p | 3.13 | -4.04 |
| 11 | hsa-miR-4454 | 10.01 | -2.37 |
| 12 | hsa-miR-200c-3p | 40.43 | 1.07 |
| 13 | hsa-miR-619-5p | 29.01 | -6.83 |
| 14 | hsa-let-7i-5p | 2 | -4.72 |
| 15 | hsa-miR-574-3p | 2.16 | -2.66 |
The miRs expression were higher in uE from DN patients, relative to age matched T2DM patients without kidney disease (DC, n=9/group). However, in renal biopsies from DN patients (n=5) the fold change in the expression was lower relative to renal biopsies collected from patients undergoing nephrectomy for renal calculus were taken as controls (Cnt, n=3). The microarray data was analyzed using TAC 4.0 analysis software.