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. 2023 May 12;14:1170357. doi: 10.3389/fimmu.2023.1170357

Table 1.

Antigen-binding kinetics of the aHSA and aMSA knob domains. Errors are standard deviations (n ≥ 3).

Knob domain Albumin species k a, M-1s-1 k d, s-1 K D, M
aHSA Human 1.1 ± 0.5 × 105 6 ± 3 × 10-3 5.7 ± 0.2 × 10-8
Cyno No binding
Mouse No binding
Rat No binding
aMSA Human No binding
Monkey No binding
Mouse 1.06 ± 0.12 × 104 2.83 ± 0.17 × 10-3 2.7 ± 0.5 × 10-7
Rat 1.1 ± 0.3 × 104 1.21 ± 0.12 × 10-2 1.2 ± 0.4 × 10-6