Table 1.
Baseline characteristics and COS and ART outcomes.
| Variable | GROUP | P value | ||||
|---|---|---|---|---|---|---|
| DOR N=66 | NOR N=160 | HOR N=141 | D VS N | D VS H | N VS H | |
| Age, y | 33.24 ± 4.22 | 29.48 ± 2.88 | 29.33 ± 2.77 | |||
| FSH, IU/L | 8.48 ± 2.65 | 7.45 ± 1.51 | 7.01 ± 1.82 | |||
| AFC | 7.77 ± 4.76 | 9.52 ± 2.00 | 15.53 ± 4.67 | |||
| AMH, ng/ml | 2.49 ± 2.33 | 2.77 ± 0.92 | 7.38 ± 2.91 | |||
| BMI, kg/m2 | 20.94 ± 2.49 | 21.46 ± 2.50 | 20.95 ± 2.22 | ns | ns | ns |
| GnRH protocol | ||||||
| antagonist | 28(42.4%) | 20(12.5%) | 9(6.4%) | <0.001 | <0.001 | ns |
| agonist | 38(57.6%) | 140(87.5%) | 132(93.6%) | <0.001 | <0.001 | ns |
| Duration of infertility, y | 3.29 ± 3.11 | 3.21 ± 2.10 | 3.02 ± 1.93 | ns | ns | ns |
| Type of endometriosis | ||||||
| endometriosis cysts | 48(72.7%) | 138(86.3%) | 126(89.4%) | ns | ns | ns |
| adenomyosis | 13(19.7%) | 12(7.5%) | 11(9.8%) | 0.024 | 0.039 | ns |
| cysts co-occurrence with adenomyosis | 5(7.6%) | 10(6.3%) | 4(2.8%) | ns | ns | ns |
| Endometrial thickness, mm | 11.76 ± 2.62 | 12.54 ± 2.71 | 12.24 ± 2.38 | ns | ns | ns |
| No. of oocytes retrieved | 8.39 ± 4.50 | 9.73 ± 4.48 | 13.94 ± 4.20 | ns | <0.001 | <0.001 |
| No. of MII | 7.76 ± 4.32 | 8.69 ± 4.24 | 12.20 ± 4.04 | ns | <0.001 | <0.001 |
| Oocyte maturation rate | 0.92 ± 0.10 | 0.89 ± 0.12 | 0.88 ± 0.13 | ns | 0.044 | ns |
| No. of 2PN | 5.38 ± 3.32 | 6.13 ± 3.42 | 8.40 ± 3.43 | ns | <0.001 | <0.001 |
| Normal fertilization rate | 0.66 ± 0.22 | 0.66 ± 0.21 | 0.64 ± 0.18 | ns | ns | ns |
| Biochemical pregnancy | 5(7.6%) | 8(5.0%) | 5(3.5%) | ns | ns | ns |
| Pregnancy loss | 10(15.2%) | 12(7.5) | 10(7.1%) | ns | ns | ns |
| Clinical pregnancy | 32(48.5%) | 96(60%) | 97(68.8%) | ns | 0.015 | ns |
| Live birth | 22(33.3%) | 84(52.5%) | 87(61.7%) | 0.027 | <0.001 | ns |
| single | 17(25.8%) | 59(36.9%) | 66(46.8%) | ns | 0.012 | ns |
| multiple | 5(7.6%) | 25(15.6%) | 21(14.9%) | ns | ns | ns |
| Cumulative pregnancy | 44(66.7%) | 129(80.6%) | 120(85.1%) | ns | 0.006 | ns |
| Cumulative live birth | 37(56.1%) | 116(72.5%) | 112(79.4%) | 0.048 | <0.001 | ns |
| single | 29(43.9%) | 84(52.5%) | 86(61.0%) | ns | ns | ns |
| multiple | 8(12.1%) | 32(20.0%) | 26(18.4%) | ns | ns | ns |
Continuous data are reported as mean ± standard deviation. Categorical data are reported as n (%). One-way analysis of variance test was used for the continuous data, and chi-square test was used for categorical data. P<0.05 was considered statistically significant. ns, not statistically significant; DOR, diminished ovarian reserve; NOR, normal ovarian reserve; HOR, high ovarian reserve; AFC, antral follicle count, FSH, follicle stimulating hormone; AMH, anti-Müllerian hormone.