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. 2023 May 12;14:1175387. doi: 10.3389/fimmu.2023.1175387

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Copyright © 2023 Yu and Lian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The molecular mechanisms of driving PMN activation in TRALI pathogenesis. Blood transfusion induces PMN activation via the generation of signaling molecules activating the receptors on PMNs, thereby exacerbating TRALI. (A) Up-regulated miR-144 promotes PMN activation through activating the NF-κB/CXCR1 signaling pathway via down-regulation of KLF2. (B) PTP1B activates PMNs via PI3Kγ/AKT/mTOR-dependent CXCR4 signaling. (C) HLA-A2 induces PMN-derived ROS production via activating NF-κB/NLRP3 inflammasome via phoosphorylate-Src elevation.