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. 2023 May 12;14:1175387. doi: 10.3389/fimmu.2023.1175387

Table 1.

Summary of the prevention strategies of TRALI.

Disease Strategy Type of study Effects Country Year Sources
Antibody
dependent
TRALI
Donor
management
Male-only plasma Retrospective study Decline in TRALI Australia 2022 Sivakaanthan et al. (21)
Retrospective study No TRALI cases reported UK 2017 Bolton-Maggs et al. (110)
Male-dominate plasma Retrospective study Decline in TRALI Australia 2022 Sivakaanthan et al. (21)
Exclusion of allo-exposure donors Prospective study Decline in TRALI Netherlands 2012 Middelburg et al. (111)
Screening for antibodies Retrospective study Decline in TRALI Germany
France
UK
Sweden
USA
2012 Reesink et al. (112)
SDP Clinical study No cases of TRALI Norway 2003 Flesland et al. (113)
Systematic review and meta-analysis No cases of TRALI Netherlands 2017 Saadah et al. (114)
Clinical study No cases of TRALI Netherlands 2020 Saadah et al. (115)
Retrospective study TRALI occurrence Netherlands 2022 Klanderman et al. (20)
Case series TRALI occurrence Netherlands 2022 Klanderman et al. (116)
Antibody
independent TRALI
Leukoreduction Retrospective study Decline in TRALI USA 2010 Blumberg et al. (117)
Preclinical study TRALI mitigation USA 2014 Silliman et al. (47)
Preclinical study TRALI mitigation USA 2020 McQuinn et al. (118)
Systematic review Invalid in prevention TRALI Ecuador 2015 Simancas-Racines et al. (119)
PRT Mirasol Preclinical study Invalid in prevention TRALI USA 2010 Silliman et al. (120)
Mirasol Preclinical study Incapable of inducing TRALI USA 2015 Caudrillie et al. (121)
Mirasol Preclinical study Incapable of inducing TRALI USA 2017 Mallavia et al. (122)
Mirasol Retrospective study Valid in prevention TRAL Ghana 2019 Owusu-Ofori et al. (123)
Intercept (TM) Prospective study No TRALI cases Italy 2015 Knutson et al. (124)
Intercept (TM) Cohort study No effect on prevention TRALI USA 2022 Snyder et al. (125)
PAS Review Reducing the incidence of TRALI USA 2019 Kuldanek et al. (126)
Review Reducing the incidence of TRALI Netherlands 2018 van der Meer et al. (127)
TRALI PBM Review Decreasing the incidence of TRALI USA 2017 Friedman et al. (128)
Retrospective study Decline the incidence of TRALI Austria 2019 Tung et al. (129)
Retrospective study Avoiding TRALI occurrence Sri Lanka 2022 Priyanjani et al. (130)

TRALI, transfusion-related acute lung injury; SDP, solvent/detergent treated pooled plasma; PRT, pathogen reduction technology; PAS, platelet additive solution; PBM, patient blood management.