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. 2023 May 12;10:1098472. doi: 10.3389/fmed.2023.1098472

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Copyright © 2023 Valero-Tena, Roca-Espiau, Verdú-Díaz, Diaz-Manera, Andrade-Campos and Giraldo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) S-MRI distribution according to age group and gender. (B) S-MRI distribution in relation to sex. (B) At baseline, S-MRI in male patients is 9.1 vs. S-MRI in female patients is 7.7 (p < 0.001). After 10 years of follow-up, the mean S-MRI in male patients is 7.0 and mean S-MRI in female patients is 4.7 after 5–9 years of follow-up. (C) Globally, the S-MRI is 8.4, and the maximum reduction is observed after 5–9 years on therapy.