TABLE 1.

DUBs involved in autophagy.

DUB	Target proteins	Regulatory mechanisms	Effects on autophagy of tumor cells
OTUB1	DEPTOR Zhao et al., 2018	It mediates DEPTOR deubiquitination and inhibits mTORC1 activity Zhao et al., 2018	Promote
USP1	ULK1 Raimondi et al., 2019	USP1 hydrolyzes the K63 ubiquitin chain of ULK1 and regulates the dynamic activity of ULK1 autophagy initiation and postinitiation Raimondi et al., 2019	Promote
USP20	. ULK1 Kim et al., 2018	USP20 hydrolyzes the K48 ubiquitin chain of ULK1 Kim et al., 2018	Promote
USP14	TAB 2 Min et al., 2017	Inhibiting TrAF6-mediated Beclin-1 K63 ubiquitination Min et al., 2017	Inhibit
USP19	Beclin1 Jin et al., 2016	Hydrolyzing the K11 ubiquitin chain at Lys 437 to protect Beclin-1 from degradation Jin et al., 2016	Promote
USP33	RALB Simicek et al., 2013	Indirectly regulating Beclin-1 by deubiquitination of RALB Simicek et al., 2013	Inhibit
	Parkin Niu et al., 2020	Hydrolyzing the K63 ubiquitin chain at Lys435 of Parkin protein Zhou et al., 2018
USP8	EPG5 Gu et al., 2019	Promoting the fusion of autophagosome and lysosome, and hydrolyzing the K63 ubiquitin chain at EPG5 Lys 252 Gu et al., 2019	Promote
	Parkin Durcan and Fon, (2015)	Hydrolyzing the K6 ubiquitin chain on Parkin Durcan and Fon, (2015)
USP35/USP15	mitochondrial protein [ Wang et al., 2015, Cornelissen et al., 2014	Reverse ubiquitination of Parkin substrates on mitochondria Wang et al., 2015, Cornelissen et al., 2014	Inhibit