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. 2023 May 25;6(8):e202201853. doi: 10.26508/lsa.202201853

Figure S13. Cytotoxicity after treatment of alveolospheres with anti-fibrotic compounds.

Figure S13.

Related to Fig 8. (A) Schematic illustrating the prophylactic treatment of alveolospheres stimulated with either the CC or the FC in the presence or absence of nintedanib or pirfenidone. (B) LDH release detected in the secreted medium of alveolospheres stimulated with either the CC or the FC in the presence or absence of nintedanib (N) or pirfenidone (P). Data presented as means of absorbance values of eight technical replicates for each batch ± SD. Repeated measures one-way ANOVA (comparisons of CC+N or P versus CC+DMSO, and FC+N or P versus FC+DMSO) performed. n = 3 batches of alveolospheres. (C) Average organoid counts per batch after stimulation with either the CC or the FC in the presence or absence of nintedanib or pirfenidone. n = 8–16 independent images from each of three batches and for each condition of alveolospheres. Repeated measures one-way ANOVA (comparisons to FC+DMSO) performed.