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. 2023 May 25;6(8):e202201853. doi: 10.26508/lsa.202201853

Figure S15. Effects of anti-fibrotic compounds on markers dysregulated by the fibrosis cocktail.

Figure S15.

Related to Fig 8. (A) Expression of genes measured by qRT–PCR. The expression of the gene in each sample was normalised to the average CT value of the reference genes GAPDH, TBP, and HPRT1. Fold changes (2−ΔΔCT) were calculated by comparison with the average ΔCT value of the CC+DMSO population. Data presented as means ± SD. Repeated measures one-way ANOVA (comparisons to FC+DMSO) performed. n = 3 batches of alveolospheres. (B) Expression of genes altered by the FC where treatment effects were nonsignificant, measured by qRT–PCR. Expression of the genes normalised to the average CT value of the reference genes GAPDH, TBP, and HPRT1. Fold changes (2−ΔΔCT) calculated by comparison with the average ΔCT value of the CC+DMSO population. Data presented as means ± SD. Repeated measures one-way ANOVA (comparisons to FC+DMSO) performed. n = 3 batches of alveolospheres. Note: Values of FC+DMSO are the same as shown in Figs 8 and S14 to allow for comparisons.