Figure 1.

Structure, downstream signaling molecules, and the known signaling outcomes of signaling lymphocytic activation molecule (SLAM)-family receptors. IgV (V)- and IgC2 (C2)-like domains are found in the extracellular areas. Via the IgV-like domain, the receptors attach to self-ligands with great affinity. The cytoplasmic tail of every family member, except for SLAMF2, SLAMF8, and SLAMF9, has an immunoreceptor tyrosine-based switch motif (ITSM). SLAMF4 has the highest number of ITSM motifs. SLAMF3 has four Ig-like domains in its extracellular domain. Positive symbols and negative symbols indicate activatory outcome and inhibitory outcome, respectively.