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. 2023 May 11;14:1174138. doi: 10.3389/fimmu.2023.1174138

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Copyright © 2023 Farhangnia, Ghomi, Mollazadehghomi, Nickho, Akbarpour and Delbandi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signaling lymphocytic activation molecule family receptor (SLAMF) 3 signal transduction in multiple myeloma (MM) cells. In MM, homotypic interactions between SLAMF3 molecules are established, stimulating the ERK signaling pathway and specific transcription factors (TFs). This pathway eventually causes survival, proliferation, migration, differentiation, and anti-apoptotic responses in MM cells, which facilitates the progression of the malignancy. Anti-SLAMF3 antibodies might restrict the development of malignancy.