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. 2023 May 11;10:1203269. doi: 10.3389/fmolb.2023.1203269

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Copyright © 2023 Zhang, Zhang, Dong, Kong and Guan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipid metabolism and ferroptosis. Both lipid anabolism and catabolism affect the content of lipid substrates for ferroptosis. PUFAs are activated by ACSL4, LPCAT3 promotes the synthesis of PUFAs-PL, and membrane PUFAs-PL are subsequently oxidized by oxygenases, such as ALOX and POR, to promote ferroptosis. Abbreviations: AA, arachidonic acid; ACAC, acetyl-CoA carboxylase; ACSLs, Long-chain fatty acid-CoA synthases; ACSMs, medium-chain acyl-CoA synthases; AdA, adrenic acid; ALOXs, arachidonate lipoxygenase; CPT1, carnitine palmitoyltransferase 1; LA, linoleic acid; LD, lipid droplet; LNA, α-linolenic acid; ELOVL5, elongation of very long-chain fatty acid protein 5; FADS1/2, fatty acid desaturases 1/2; FASN, fatty acid synthetase; LPCAT3, lysophosphatidylcholine acyltransferase 3; POR, Cytochrome P450 reductase.