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. 2023 Apr 19;4(5):101020. doi: 10.1016/j.xcrm.2023.101020

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

PET imaging characteristics of [¹¹C]K-2 and positive correlation between the amount of cell-surface AMPARs and the amplitude of gamma activity in patients with the focal-onset seizures

(A) Averaged TACs in the brains of patients with the focal-onset seizures (n = 22). The analysis was performed on 10 brain regions from a whole brain region, of which 6 representative regions are shown. Data are shown as the mean ± SD.

(B) Logan graphical analysis (LGA) plot showing the ratio between an integrated tissue TAC in the reference region (white matter; C_R) and a tissue TAC (C) (x axis) plotted against the ratio of integrated C with C itself (y axis).

(C) Correlation between SUVR_30–50 min − 1 and BP_ND obtained from LGA in 10 brain regions with focal-onset seizures (n = 22; two-tailed Spearman correlation analysis: correlation coefficient = 0.996, p < 0.0001, y = 0.9866x − 0.02555). Each spot represents BP_ND (x axis) and the SUVR_30–50 min − 1 (y axis), which was obtained from 10 brain regions of each patient.

(D) The EEG law data in the patients with the focal-onset seizures with the highest (top) and lowest (bottom) gamma power at the F8 electrode that correlated with SUVR_30–50 min.

(E) The power spectrum density in the patients with the focal-onset seizures with the highest (left) and lowest (right) gamma power at the F8 electrode that correlated with SUVR_30–50 min. The power spectral density of the EEG was calculated by averaging short-time Fourier transforms of 2-s moving windows.

(F) SPM analysis of [¹¹C]K-2 in patients with the focal-onset seizures identifies the brain regions showing a significant positive correlation between SUVR_30–50 min with white matter as a reference and the amplitude of gamma activity in the F8 electrode site (p < 0.05, T > 1.72, one-tailed, FDRc [false discovery rate correction]). Color scale bar indicates T value of this correlation. R, right side; L, left side; A, anterior side; P, posterior side.

(G) Scatterplot analysis of [¹¹C]K-2 in patients with focal-onset seizures shows strong positive correlation between [¹¹C]K-2 SUVR_30–50 min of colored region in (F) and the amplitude of gamma activity in the F8 electrode site (n = 22, Spearman correlation analysis; correlation coefficient = 0.4828, p = 0.0229). Each spot corresponds to SUVR_30-50 min (x axis) and the amplitude of the gamma activity at F8 (y axis) of a single patient, and 22 spots obtained from 22 patients are displayed.