Figure 6.

A potential mechanism for the progression to FBTCS: Spread of disinhibition can underlie the generalized seizure developed from focal-onset seizure

(Left) In patients with focal-onset seizures without generalized seizure, excitation is under control to some degree by the inhibition augmented by increased AMPARs in the same region where AMPAR-coupled pathological upregulation of excitation is observed. (Right) In patients with FBTCSs, AMPAR-coupled disinhibition is considered to spread in the brain, which can shift from focal to generalized seizures.