Figure 5.

In vivo efficacy of MHV370 in the NZB/W F1 lupus model

(A) Proteinuria. Lines represent individual mice.

(B) BUN levels at termination. ∗p < 0.05, ANOVA with Dunnett’s post test.

(C) Kidney histopathology and glomerulopathy score.

(D) IgG deposition in kidneys and score.

(E) B cell infiltration in kidneys and score.

(F) CXCL13 protein levels in serum at termination. ∗∗p < 0.01, ∗∗∗p < 0.001, ANOVA with Dunnett’s post test.

(G) Correlation of CXCL13 levels in serum with glomerular IgG deposition; dotted line, 95% confidence interval.

In (B) to (G), data points represent individual mice, in (B) to (F), means ± SD. Open symbols, vehicle-treated mice; open squares, vehicle-treated mice which were terminated prematurely as they reached the humane endpoint of the license. In (C) to (E), ∗p < 0.05, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, Mann-Whitney test. Scale bars, 50 μm.

See also Figures S4–S6.