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MHV370 inhibition of TLR7, TLR8, and TLR9 responses
| Cells | TLR7 (ssRNA-IFN-α) | TLR8 (ssRNA-TNF) | TLR9 (ODN-IFN-α) |
|---|---|---|---|
| Human PBMCs | 4.1 ± 0.4 (39) | 70 ± 7.4 (37) | 1,300 ± 170 (20) |
| Human blood | 8.4 ± 1.0 (16) | 31 ± 4.4 (14) | 1,320 ± 150 (12) |
| Mouse blood | 58 ± 10 (7) | 12 ± 4.2 (3)a | >10,000 (4) |
IC50 values (nM) shown are the mean ± SEM of (n) separate experiments or donors.
Murine response driven via TLR7.
