Figure 2.

Single-cell transcriptional profiling of colonic ILCs, NK cells, and T cells in pIBD colitis

(A) Schematic illustration of the scRNA-seq workflow of the total 12 paired colonic biopsy samples obtained from the endoscopically least and most inflamed areas of the 6 pediatric patients with CD-colitis (n = 6 donors).

(B) UMAP visualization of the scRNA-seq data showing the unbiased clustering of total 44 717 ILCs, NK cells, and T cells.

(C) Dotplot displaying expression of lineage-identity genes for the annotation of the clusters in (B).

In (A)–(C), cells from each donor were analyzed in independent experiments.