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. 2023 May 4;14:1167873. doi: 10.3389/fphys.2023.1167873

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Copyright © 2023 Pierce and Hougland.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structures of PORCN bound to substrates. (A) Overall structure of PORCN with 11 transmembrane domains and both the N-terminus and C-terminus in the ER lumen. (B) PORCN in complex with palmitoyl-CoA (orange) (PDB ID 7URA), showing the bound zinc ion (magenta) and palmitic acid (green). The antibody structural chaperone is shown in wheat. Figure created using Biorender.