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Computational model of ghrelin O-acyltransferase (GOAT). GOAT has 11 transmembrane helices and a transmembrane catalytic channel containing amino acids required for activity such as His 338 (green) and Asn 307 (blue) and residues implicated in acyl donor selectivity such as Trp351 and Phe331 (purple). The luminal pore for ghrelin binding and the catalytic channel can be seen in the top view from the luminal face of the membrane (right). Figure created using Biorender.
