FIGURE 5.

Independently determined structures of ACAT1/SOAT1 reveal common characteristics. All three published ACAT1/SOAT1 structures are consistent in identifying a multimeric complex, with at least two structures of the three also containing bound acyl donor and/or an inhibitor bound in the catalytic core of the enzyme. Different colors denote each monomeric unit within the dimeric or tetrameric complexes. Bound inhibitors are shown in purple, and acyl donor analogs are in orange. Figure created using Biorender.