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. 2023 May 4;14:1167873. doi: 10.3389/fphys.2023.1167873

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Copyright © 2023 Pierce and Hougland.

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Structure of ACAT2/SOAT2 bound to the PPPA inhibitor. (A) ACAT2/SOAT2 forms a tetramer, but only requires dimer formation for acylation activity. Monomers are shown in gray, blue, pink, and purple, and the PPPA inhibitor in each monomer is hot pink. (B) One molecule of PPPA binds per monomer of ACAT2/SOAT2, contacting residues Val489, Gln488, and Phe438. PDB ID: 7N6Q. Figure created using Biorender.