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DGAT1 is a dimeric enzyme with a central cavity and a lateral gate. Independent structures confirm the formation of functional dimers (blue and dark gray), with a lateral gate for substrate access denoted by black arrows on each structure’s top view from the luminal face (right). Both structures contain a non-hydrolyzable CoA analog in orange. (A) Structure by Wang and co-workers (PDB ID 6VP0). (B) Structure by Sui and co-workers (PDB ID 6VZ1). Figure created using Biorender.
