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. Author manuscript; available in PMC: 2024 May 26.
Published in final edited form as: Circ Res. 2023 May 25;132(11):1521–1545. doi: 10.1161/CIRCRESAHA.123.321563

Figure 5. Current classes of small molecule scavengers available to target reactive lipid carbonyls.

Figure 5.

Thiol-based scavengers capture ACR (acrolein), ONE (4-oxo-nonenal), and HNE (4-hydroxy-nonenal). Imidazole-based scavengers capture ACR, ONE, HNE, and MGO (methylglyoxal). 2-aminomethylphenol-based dicarbonyl scavengers capture IsoLG (isolevuglandins), ONE, MDA (malondialdehyde), and MGO.