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. 2023 May 16;120(21):e2218478120. doi: 10.1073/pnas.2218478120

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Copyright © 2023 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 5. — Cross-cell type generalizability of trisomy 21 effects on gene expression. (A) Bar graph shows the statistical significance, −log10(p), of enrichment tests in each of 22 autosomes and the X chromosome for a preidentified set of 500 genes that show consistently DE in comparisons of euploid vs. trisomy 21 samples. Only human chromosome 21 (chr21) genes survive Bonferroni correction. (B) Heat map shows the result of Fisher’s exact tests of overlaps of chr21(Upper row) and non-chr21 (Lower) DEGs between a pair of tissues. All −log10(p) values shown in color survive Bonferroni correction (Materials and Methods).