Table 1.
Genes with obligate dosage sensitivity (ODS) to X chromosome dosage changes in lymphoblastoid cell lines (LCLs)
| Ensembl ID | Symbol | Chr | Gene description | X Escape | Y Gametolog |
|---|---|---|---|---|---|
| ENSG00000005889 | ZFX | X | Regulation of transcription, multicellular organism development | Yes | ZFY |
| ENSG00000006757 | PNPLA4 | X | Lipid metabolic process, triglyceride catabolic process | Yes | |
| ENSG00000069509 | FUNDC1 | X | An activator of hypoxia-induced mitophagy | Yes | |
| ENSG00000072501 | SMC1A | X | Chromosome cohesion during cell cycle and in DNA repair | Yes | |
| ENSG00000086712 | TXLNG | X | Regulation of cell cycle | Yes | TXLNGY |
| ENSG00000126012 | KDM5C | X | Chromatin organization, chromatin remodeling | Yes | KDM5D |
| ENSG00000130021 | PUDP | X | Yes | ||
| ENSG00000130741 | EIF2S3 | X | GTP binding and translation initiation factor activity | Yes | |
| ENSG00000130985 | UBA1 | X | Timely DNA repair and for response to replication stress | Yes | |
| ENSG00000147050 | KDM6A* | X | In utero embryonic development, chromatin organization | Yes | UTY |
| ENSG00000169249 | ZRSR2 | X | Spliceosomal complex assembly, RNA splicing | Yes | |
| ENSG00000173674 | EIF1AX* | X | Translation, translational initiation | Yes | EIF1AY |
| ENSG00000183943 | PRKX | X | Endothelial cell proliferation, signal transduction | Yes | PRKY |
| ENSG00000198034 | RPS4X | X | Multicellular organism development, translational initiation | Yes | RPS4Y1/RPS4Y2 |
| ENSG00000215301 | DDX3X | X | Immune system process, regulation of translation | Yes | DDX3Y |
| ENSG00000225470 | JPX | X | Positive regulation of gene expression | Yes | |
| ENSG00000229807 | XIST* | X | Dosage compensation by inactivation of X chromosome | Yes | |
| ENSG00000285679 | Lnc-VCX-2 | X | Yes |