Table 2.
Genes with obligate dosage sensitivity (ODS) to Y chromosome dosage changes in lymphoblastoid cell lines (LCLs)
| Ensembl ID | Symbol | Chr | Gene description | X Gametolog |
|---|---|---|---|---|
| ENSG00000012817 | KDM5D | Y | Chromatin organization, chromatin remodeling | KDM5C |
| ENSG00000067048 | DDX3Y* | Y | Gamete generation, cell differentiation | DDX3X |
| ENSG00000067646 | ZFY* | Y | Regulation of transcription, DNA-templated | ZFX |
| ENSG00000099725 | PRKY | Y | Protein phosphorylation, signal transduction | PRKX |
| ENSG00000114374 | USP9Y* | Y | Proteolysis, spermatogenesis, cell migration | USP9X |
| ENSG00000129824 | RPS4Y1 | Y | Multicellular organism development, translational initiation | RPS4X |
| ENSG00000131002 | TXLNGY | Y | Syntaxin binding | TXLNG |
| ENSG00000154620 | TMSB4Y* | Y | Actin filament organization, regulation of cell migration | TMSB4X |
| ENSG00000165246 | NLGN4Y | Y | Cell adhesion, chemical synaptic transmission, learning | NLGN4X |
| ENSG00000183878 | UTY* | Y | Chromatin organization, regulation of gene expression | UTX |
| ENSG00000198692 | EIF1AY | Y | Translation, translational initiation | EIF1AX |
| ENSG00000231535 | LINC00278 | Y | ||
| ENSG00000241859 | ANOS2P | Y | A pseudogene, associated with Kallmann Syndrome | |
| ENSG00000260197 | Lnc-KDM5D-1 | Y | ||
| ENSG00000286009 | AC244213.1 | Y |