Table 3.

Genes with obligate dosage sensitivity (ODS) to total sex chromosome dosage changes in lymphoblastoid cell lines (LCLs)

Ensembl ID	Symbol	Chr	Gene description (associated diseases)	PAR1	Location
ENSG00000169084	DHRSX	X	Cholesterol ester storage disease and partington X-linked mental retardation syndrome	Yes	Xp22.33 and Yp11.2
ENSG00000169093	ASMTL	X	Melanotic neurilemmoma and chronic tic disorder	Yes	Xp22.3 and Yp11.3
ENSG00000169100	SLC25A6	X	Influenza and bubonic plague	Yes	Xp22.32 and Yp11.3
ENSG00000178605	GTPBP6	X	Sengers syndrome and mongolian spot	Yes	Xp22.33 and Yp11.32
ENSG00000182162	P2RY8	X	Childhood B cell acute lymphoblastic leukemia and B-lymphoblastic leukemia/lymphoma with Iamp21	Yes	Xp22.33 and Yp11.3
ENSG00000197976	AKAP17A	X	Hodgkin's lymphoma, mixed cellularity and autism	Yes	Xp22.33 and Yp11.32
ENSG00000214717	ZBED1	X	Chronic tic disorder and retinitis pigmentosa	Yes	Xp22.33 and Yp11
ENSG00000228223	HCG11	6

All of these 8 ODS genes except HCG11 are on PAR1.