REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-NLRP3 antibody	Adipogen	AG-20B-0014
Anti-NLRP3 antibody	Novus	NBP2-12446SS
Anti-Caspase 1 antibody	Adipogen	AG-20B-0042
Anti-Caspase 1 antibody	Proteintech	22915-1-AP
Anti-IL1β antibodies	R&D Systems	AF-401-SP
Bacterial and virus strains
Adenovirus producing β-galactosidase	This paper	N/A
Adenovirus producing adipolin	This paper	N/A
Chemicals, peptides, and recombinant proteins
MCC950	Adipogen	AG-CR1-3615
GW6471	Cayman	11697
SB431542	Cayman	13031
LY294002	Cell Signaling Technology	#9901
Recombinant angiotensin II protein	Sigma-Aldrich	A9525
Critical commercial assays
Masson’s trichrome assay kit	Sigma-Aldrich	HT15
β-hydroxybutyrate and a ketone Body assay kit	Cayman	700190
TUNEL Assay kit-HRP-DAB	Abcam	AB20638
Plasma UN and Cr measurement	SRL	commercial laboratory
Urine Cr measurement	SRL	commercial laboratory
murine albumin enzyme-linked immunosorbent assay kit	Exocell	1011
PPARα transcription factor assay kit	Cayman	10006915
dual-luciferase reporter assay system	Promega	E1910
Experimental models: Cell lines
Human HK-2 cell	ATCC	CRL2190
Mouse MPC-5 podocyte clonal cell	University of Bristol	N/A
Experimental models: Organisms/strains
Mouse C57BL/6J	Jackson Laboratories	Strain No. 000664
Adipolin knockout mice	This paper	N/A
PPARα knockout mice (B6; 129S4-Pparatm1Gonz/J)	Jackson Laboratories	Strain No. 008154
Oligonucleotides
siRNA targeting nontargeting pool	Horizon Discovery	D-001810-10
siRNA targeting HMGCS2 (ON-TARGETplus, SMARTpool)	Horizon Discovery	L-010179-00
siRNA targeting PPARα (ON-TARGETplus, SMARTpool)	Horizon Discovery	L-003434-00
siRNA targeting AdipoR1 (ON-TARGETplus, SMARTpool)	Horizon Discovery	L-007800-01
siRNA targeting AdipoR2 (ON-TARGETplus, SMARTpool)	Horizon Discovery	L-007801-01
Software and algorithms
image J analysis system	Schneider et al.40	Nat Methods 9, 671–675. 10.1038/nmeth.2089
JMP Pro 15 software	SAS	N/A