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. 2023 Apr 26;9(5):892–904. doi: 10.1021/acscentsci.3c00015

Figure 3.

Figure 3

Binding affinities of PINADs and their parent molecules. (a) Affinity measurements of the PDS family toward the 5′ UTR NRAS oligonucleotide in a K+ buffer, as determined via a fluorescence quenching assay. (b) Affinity measurements of the MTDB family toward a betacoronaviral pseudoknot oligonucleotide, as measured via an MST initial fluorescence scan. (c) Affinity measurements of Click-Degrader 1 toward the G4 and pseudoknot constructs, as measured via MST thermophoresis curve analysis (n = 3).