Figure 2.

Generation and re-fusion of osteomorphs

(A) Representative images of immunofluorescence staining (Fbxo7, green; DAPI, blue) in BMMs, fused osteoclasts, and osteoclasts undergoing fission (n = 5). Yellow dotted circles indicate large osteoclasts. The red arrowhead indicates osteoclasts undergoing fission.

(B) Representative images showing osteoclast division and re-fusion. Red arrowhead indicates osteoclasts undergoing fission. Purple arrowhead indicates osteoclasts undergoing re-fusion. Yellow arrowheads indicate the re-fused osteoclasts generated after treatment with RANKL for 12 h.