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Relationship between mitophagy and osteoclast fate
Large osteoclasts are formed by fusion of macrophagys. After formation, there are two distinct fates for osteoclasts. Most of them undergo fission and transform into osteomorphs, in which mitophagy plays a significant role. And osteomorphs could re-fuse back to osteoclasts to perform a bone resorption function when treated with RANKL again. If mitophagy is suppressed, osteoclasts will undergo apoptosis.
