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. Author manuscript; available in PMC: 2023 Aug 23.
Published in final edited form as: Compr Physiol. 2022 Aug 23;12(4):3781–3811. doi: 10.1002/cphy.c210029

Figure 7.

Figure 7.

Schematic representation of the perfused boundary region (PBR) that allows for assessment of in vivo endothelial glycocalyx thickness. Flowing red blood cells (RBC) form a column as they travel within the vascular lumen. Blood velocity and the electrostatic charges of the endothelial glycocalyx as well as those of RBCs form a PBR, where only a few RBCs occasionally penetrate. The size of the median RBC column width subtracted from the vascular luminal diameter represents a measure of the PBR and the thickness of the endothelial glycocalyx. The figure was modified from (56).