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. 2023 Apr 28;12(5):1022. doi: 10.3390/antiox12051022

Figure 1.

Figure 1

HUA progresses to HN with the aggravation of renal function injury. (A) Body weight (BW) in the indicated groups. (B) Kidney index (kidney weight–to–body weight ratios) in the indicated groups. (C) SUA level in the indicated groups. (D) Scr in the indicated groups. (E) BUN in the indicated groups. (F) GFR in the indicated groups. (G–I) Correlation between SUA with various parameters of kidney function: Scr (G), BUN (H), and GFR (I). (J) Hematoxylin and eosin (H&E, up) staining and Masson (down) staining of kidney tissue. Black arrows represent dilation, blue arrows represent atrophy, and yellow arrows represent loss of brush borders. Green arrows represent collagen deposits that are stained blue. Scale bar, 50 μm. (K) Quantification of tubular injury score in mouse kidney sections. (L) Quantification of Masson-stained positive areas in mouse kidney sections. Data represent means ± SEM. ** p < 0.01 and *** p < 0.001 vs. wild-type mice injected with inducer for 0 day. Data for each mouse are illustrated with the number of mice indicated in parentheses (G–I) or the data are from the kidneys of six mice (A–F, J–L).