Table 1.

Results of MAO-A and MAO-B inhibition by the synthesized compounds (3aa–3bd).

Compound	X	n1	n2	R1	% Inhibition
					MAO-A 1	MAO-B 2
3aa	No atoms	1	0	2′-methoxy	NI 3	91.49 ± 0.27
3ab	CH2	0	0	2′-methoxy	NI	43.00 ± 0.55
3ac	CH2	0	1	2′-methoxy	1.31 ± 0.82	32.27 ± 0.23
3ad	No atoms	1	0	3′-methoxy	NI	46.09 ± 0.11
3ae	No atoms	1	1	3′-methoxy	NI	18.76 ± 0.45
3af	CH2	0	0	3′-methoxy	NI	39.11 ± 0.96
3ag	CH2	0	1	3′-methoxy	12.24 ± 1.05	16.99 ± 0.11
3ah	CH2	1	1	3′-methoxy	NI	18.07 ± 1.83
3ai	O	1	0	3′-methoxy	4.1 ± 0.48	27.87 ± 0.37
3aj	CH2	0	0	4′-methoxy	3.26 ± 0.75	39.26 ± 0.03
3ak	CH2	0	1	4′-methoxy	9.83 ± 0.64	45.64 ± 0.08
3al	CH2	0	2	4′-methoxy	NI	49.80 ± 0.02
3am	CH2	1	0	4′-methoxy	0.92 ± 0.83	20.56 ± 0.79
3an	CH2	0	0	3′,4′-dimethoxy	NI	48.06 ± 1.46
3ao	CH2	0	1	3′,4′-dimethoxy	NI	39.21 ± 0.58
3ap	CH2	1	0	3′,4′-dimethoxy	NI	50.81 ± 0.44
3aq	CH2	1	1	3′,4′-dimethoxy	NI	4.51 ± 1.30
3ar	CH2	1	2	3′,4′-dimethoxy	NI	3.89 ± 1.63
3as	CH2	1	3	3′,4′-dimethoxy	NI	4.76 ± 1.91
3at	CH2	0	0	3′,5′-dimethoxy	NI	36.84 ± 0.44
3au	CH2	0	1	3′,5′-dimethoxy	NI	21.20 ± 0.30
3av	CH2	0	0	2′,3′-dimethoxy	12.56 ± 0.32	2.61 ± 1.78
3aw	CH2	0	0	2′,4′-dimethoxy	12.73 ± 0.54	41.64 ± 1.03
3ax	CH2	0	0	2′,5′-dimethoxy	NI	65.05 ± 0.43
3ay	CH2	0	1	2′,3′-dimethoxy	NI	4.37 ± 0.90
3az	CH2	0	1	2′,4′-dimethoxy	NI	35.87 ± 0.17
3ba	CH2	0	1	2′,5′-dimethoxy	NI	20.33 ± 0.49
3bb	CH2	0	0	2′,3′,4′-trimethoxy	NI	23.90 ± 0.81
3bc	CH2	0	0	3′,4′,5′-trimethoxy	NI	99.30 ± 0.38
3bd	CH2	1	0	3′,4′,5′-trimethoxy	NI	27.93 ± 0.36

¹ Percent inhibition (±sem values) of enzyme activity at a single dose concentration of 1 µM., ² Percent inhibition (±sem values) of enzyme activity at a single dose concentration of 10 µM., ³ NI: no measured inhibition.