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. 2023 Apr 29;12(5):1033. doi: 10.3390/antiox12051033

Table 2.

IC50 values for MAO-A, MAO-B, and AChE as well as MAO-B inhibition selectivity indices for the most promising compounds.

graphic file with name antioxidants-12-01033-i002.jpg

Compound X n1 n2 R1 MAO-A MAO-B MAO-B Selectivity Index AChE IC50 (µM) 3
% Inhibition 1 IC50 (µM) 2 IC50 (µM) 2
3aa No atoms 1 0 2′-methoxy 27.18 ± 2.94 >100 0.96 ± 0.004 >104 2.67 ± 0.05
3al CH2 0 2 4′-methoxy 14.89 ± 3.46 >100 8.65 ± 0.196 >12 1.42 ± 0.09
3ap CH2 1 0 3′,4′-dimethoxy 22.52 ± 0.04 >100 10.18 ± 0.099 >9.8 0.40 ± 0.03 [30]
3ax CH2 0 0 2′,5′-dimethoxy 27.70 ± 4.95 >100 3.16 ± 0.036 >32 1.49 ± 0.31 [30]
3bc CH2 0 0 3′,4′,5′-trimethoxy 21.37 ± 3.51 >100 0.34 ± 0.002 >289 1.56 ± 0.07 [30]
Safinamide ND ND 0.11 ± 0.004 ND —
Clorgyline 100.49 ± 0.03 0.005 ± 0.0002 ND ND —
Galantamine ND ND ND ND 4.69 ± 0.12 [30]

1 Percent inhibition (±sem values) of MAO-A activity at a single dose concentration of 100 µM., 2 IC50: Concentration (±sem values) of the synthesized compound expressed in µM value that inhibits 50% of MAO-A/MAO-B activity., 3 IC50: Concentration (±SD values) of the synthesized compound expressed in µM value that inhibits 50% of AChE activity.