Table 1.

Summary of transcriptome expression in response to MG infection in chicken tracheal and lung tissues.

Animal	Sample	Groups	Pathways	Reference
5-week SPF female chicken	Tracheal epithelial cells	CG vs. MG Rlow, Rhigh, Rlow LAMP, and Rhigh LAMP	Up: TLRs, TNF-α/NF-kB, adipogenesis, senescence and autophagy, MAPK, apoptosis, EGFR1, Type II interferon	[11]
5-week SPF chicken	1, 3, 5, and 7 days after challenge Tracheal	CG vs. MG Rlow	Up: apoptosis, TLRs, MAPK, JAK-SAT, NKC mediated cytotoxicity, CCRI, intestinal immune network for IgA production	[12]
5-week SPF chicken	1 and 2 days after infection Tracheal lumen cell	CG vs. MG Rlow, GT5, and Mg7	Up: CCRI, MAPK, NOD receptor, JAK-SAT, TLRs	[13]
5-week SPF chicken	6 days after infection Tracheal rings	CG/H3N8 vs. MGRlow/H3N8	Up: phagosome, cell adhesion molecules, intestinal immune network for IgA production, JAK/STAT, TLRs Down: cardiac muscle contraction, purine metabolism, oxidative phosphorylation	[14]
10d chick	3 days after infection Lung tissue	CG vs. MG Rlow/E. coli O78	Up: CCRI, phagosome, IL-17, NF-κB, cell adhesion molecules	[15]
70-week or 4-week SPF chicken	Two weeks after challenge Tracheal tissues	CG vs. MG Asp3A	Up: DNA replication, cell cycle, CCRI, TLRs, phagosome, Down: formation and motor movement of the cilia, adherens junctions, tight junctions	[5]
3-week SPF chicken	15 days after infection Tracheal	CG vs. MG-HY	Up: cell adhesion molecules, phagosome, MAPK, calcium, and PPAR Down: Tight, ECM-receptor interaction, focal, AMPK, p53, Rap1, regulation of actin	[16]