Table 2.

Substrates present in microfluidic devices to achieve the BBB cellular architecture. In the literature, porous membranes based on inert material and hydrogels can be used to mimic the extracellular matrix.

Semipermeable Porous Membrane	Hydrogel	References
Polycarbonate	Collagen and hyaluronic acid	Ahn et al. [60] Boot et al. [61] Brown et al. [62] Jeong et al. [55] Shao et al. [63] Wang et al. [64]
Polyester	Collagen	Bonakdar et al. [65] Choi et al. [66] Falanga et al. [67] Santa-Maria et al. [58]
Poly(D-L-lactic acid)	Fibrin	Mancinelli et al. [68]
Polyethylene terephthalate	-	Meena et al. [69] Motallebnejad et al. [70] Tu et al. [56]
Silicon	-	Hudecz et al. [71] Mossu et al. [72]