Figure 1.

The relations between different concentrations of the tested drugs and the reduction in biomass. The percent reduction of biofilm biomass for each drug-containing well was calculated in comparison with the biofilm biomass formed in the absence of any drug (growth control). The lowest concentration showing a ≥50% reduction in biofilm biomass in comparison with the growth control was determined. For C. albicans and C. glabrata, sertraline showed significantly more reduction in biomass than reboxetine. For C. krusei, sertraline and reboxetine are equal. C. albicans appeared to be much more resistant to the effect of both drugs in comparison to the other species. * Significance versus reboxetine of the same concentration.