Figure 2.

The relations between different concentrations of the tested drugs and the impairment of metabolic viability of C. albicans. The minimal REB or SER concentration that causes a 50% reduction in biofilm metabolic activity when compared with the respective growth control (absence of drug) is defined as sessile cell minimal inhibitory concentration (SMIC50). Sertraline has a slight advantage over reboxetine at lower concentrations. Fluconazole and itraconazole are almost equal and generally produce more significant reductions in metabolic activity when compared to sertraline and reboxetine. * Significance versus reboxetine of the same concentration. † Significance versus sertraline of the same concentration.