Figure 3.

The relations between different concentrations of the tested drugs and the impairment of metabolic viability of C. Krusei. The minimal REB or SER concentration that causes a 50% reduction in biofilm metabolic activity when compared with the respective growth control (absence of drug) is defined as sessile cell minimal inhibitory concentration (SMIC50). Reboxetine produces more significant reduction of metabolic activity when compared to sertraline. Fluconazole and itraconazole are almost equal and generally produce more significant reduction of metabolic activity when compared to sertraline and reboxetine. * Significance versus reboxetine of the same concentration. † Significance versus sertraline of the same concentration.