Table 3.
Ingenuity-pathway-analysis-based transcriptome profiles of the 12 h-stored hBM-MSCs.
| Entrez Gene Name | Symbol | Entrez Gene ID a | Location | Fold Change b |
|---|---|---|---|---|
| ATP binding cassette subfamily C member 1 | ABCC1 | 4363 | Plasma Membrane | −1.984 |
| ABL proto-oncogene 2, non-receptor tyrosine kinase | ABL2 | 27 | Cytoplasm | 1.744 |
| argonaute RISC catalytic component 2 | AGO2 | 27,161 | Cytoplasm | −1.588 |
| AKT serine/threonine kinase 3 | AKT3 | 10,000 | Cytoplasm | −2.393 |
| alkB homolog 1, histone H2A dioxygenase | ALKBH1 | 8846 | Cytoplasm | −1.83 |
| angiopoietin 1 | ANGPT1 | 284 | Extracellular Space | −1.869 |
| amyloid beta precursor protein | APP | 351 | Plasma Membrane | 1.506 |
| aryl hydrocarbon receptor nuclear translocator | ARNT | 405 | Nucleus | 1.749 |
| activating transcription factor 3 | ATF3 | 467 | Nucleus | 2.535 |
| activating transcription factor 6 | ATF6 | 22,926 | Cytoplasm | 1.56 |
| ATM serine/threonine kinase | ATM | 472 | Nucleus | −1.523 |
| BCL2 associated X, apoptosis regulator | BAX | 581 | Cytoplasm | −2.51 |
| BCL2 apoptosis regulator | BCL2 | 596 | Cytoplasm | −1.646 |
| BCL2 like 13 | BCL2L13 | 23,786 | Cytoplasm | −2.078 |
| BCL6 corepressor | BCOR | 54,880 | Nucleus | 1.656 |
| basic helix-loop-helix ARNT like 1 | BMAL1 | 406 | Nucleus | −1.562 |
| 3′(2′), 5′-bisphosphate nucleotidase 1 | BPNT1 | 10,380 | Nucleus | 1.565 |
| bromodomain containing 3 | BRD3 | 8019 | Nucleus | 2.089 |
| calmodulin regulated spectrin associated protein family member 2 | CAMSAP2 | 23,271 | Cytoplasm | −1.955 |
| cell division cycle and apoptosis regulator 1 | CCAR1 | 55,749 | Nucleus | −1.579 |
| C-C motif chemokine ligand 2 | CCL2 | 6347 | Extracellular Space | −1.655 |
| CD200 molecule | CD200 | 4345 | Plasma Membrane | 1.713 |
| cyclin dependent kinase 12 | CDK12 | 51,755 | Nucleus | 1.849 |
| cyclin dependent kinase 13 | CDK13 | 8621 | Nucleus | −1.555 |
| cAMP responsive element binding protein 1 | CREB1 | 1385 | Nucleus | −1.68 |
| cAMP responsive element modulator | CREM | 1390 | Nucleus | 1.601 |
| cathepsin V | CTSV | 1515 | Cytoplasm | 1.573 |
| cytoglobin | CYGB | 114,757 | Cytoplasm | 2.378 |
| disco interacting protein 2 homolog A | DIP2A | 23,181 | Nucleus | 1.549 |
| dystonin | DST | 667 | Plasma Membrane | 2.201 |
| dystrobrevin alpha | DTNA | 1837 | Plasma Membrane | 2.069 |
| early growth response 1 | EGR1 | 1958 | Nucleus | 1.786 |
| eukaryotic translation initiation factor 2 alpha kinase 4 | EIF2AK4 | 440,275 | Cytoplasm | 1.576 |
| elongator acetyltransferase complex subunit 1 | ELP1 | 8518 | Cytoplasm | −2.024 |
| endoglin | ENG | 2022 | Plasma Membrane | −1.629 |
| endothelial PAS domain protein 1 | EPAS1 | 2034 | Nucleus | −3.025 |
| EPH receptor B2 | EPHB2 | 2048 | Plasma Membrane | 1.591 |
| erythropoietin receptor | EPOR | 2057 | Plasma Membrane | 2.778 |
| endoplasmic reticulum to nucleus signaling 1 | ERN1 | 2081 | Cytoplasm | −1.588 |
| Fas cell surface death receptor | FAS | 355 | Plasma Membrane | 2.388 |
| fibroblast growth factor receptor 2 | FGFR2 | 2263 | Plasma Membrane | −1.515 |
| fibronectin 1 | FN1 | 2335 | Extracellular Space | −2.059 |
| glial cell derived neurotrophic factor | GDNF | 2668 | Extracellular Space | 1.512 |
| glycerol-3-phosphate dehydrogenase 2 | GPD2 | 2820 | Cytoplasm | −1.54 |
| histone deacetylase 4 | HDAC4 | 9759 | Nucleus | 1.563 |
| hes family bHLH transcription factor 1 | HES1 | 3280 | Nucleus | 5.645 |
| heat shock protein 90 beta family member 1 | HSP90B1 | 7184 | Cytoplasm | −1.51 |
| interferon gamma inducible protein 16 | IFI16 | 3428 | Nucleus | −1.892 |
| interleukin 1 receptor type 1 | IL1R1 | 3554 | Plasma Membrane | −2.05 |
| interleukin 6 | IL6 | 3569 | Extracellular Space | 1.777 |
| Jun proto-oncogene, AP-1 transcription factor subunit | JUN | 3725 | Nucleus | 1.827 |
| lysine demethylase 6A | KDM6A | 7403 | Nucleus | −2.947 |
| KIT ligand | KITLG | 4254 | Extracellular Space | −1.654 |
| KLF transcription factor 2 | KLF2 | 10,365 | Nucleus | 1.979 |
| leptin receptor | LEPR | 3953 | Plasma Membrane | −1.507 |
| lamin B1 | LMNB1 | 4001 | Nucleus | −2.167 |
| LDL receptor related protein associated protein 1 | LRPAP1 | 4043 | Plasma Membrane | −1.845 |
| LYN proto-oncogene, Src family tyrosine kinase | LYN | 4067 | Cytoplasm | −2.418 |
| mitogen-activated protein kinase 1 | MAPK1 | 5594 | Cytoplasm | −1.564 |
| MAPK activated protein kinase 2 | MAPKAPK2 | 9261 | Nucleus | 1.95 |
| MET proto-oncogene, receptor tyrosine kinase | MET | 4233 | Plasma Membrane | −2.447 |
| mitofusin 2 | MFN2 | 9927 | Cytoplasm | −1.554 |
| MIA SH3 domain ER export factor 3 | MIA3 | 375,056 | Cytoplasm | −1.621 |
| matrix metallopeptidase 14 | MMP14 | 4323 | Extracellular Space | −1.7 |
| nuclear receptor coactivator 3 | NCOA3 | 8202 | Nucleus | −2.462 |
| neuronal growth regulator 1 | NEGR1 | 257,194 | Plasma Membrane | −1.799 |
| NFE2 like bZIP transcription factor 2 | NFE2L2 | 4780 | Nucleus | −1.85 |
| nuclear transcription factor Y subunit alpha | NFYA | 4800 | Nucleus | −1.914 |
| nicotinamide nucleotide transhydrogenase | NNT | 23,530 | Cytoplasm | −1.592 |
| notch receptor 2 | NOTCH2 | 4853 | Plasma Membrane | 1.741 |
| nuclear receptor subfamily 3 group C member 1 | NR3C1 | 2908 | Nucleus | 2.526 |
| nuclear receptor subfamily 4 group A member 1 | NR4A1 | 3164 | Nucleus | 2.282 |
| nuclear receptor subfamily 4 group A member 2 | NR4A2 | 4929 | Nucleus | 5.217 |
| O-linked N-acetylglucosamine (GlcNAc) transferase | OGT | 8473 | Cytoplasm | 1.511 |
| programmed cell death 4 | PDCD4 | 27,250 | Nucleus | 2.085 |
| phosphatidylinositol 3-kinase catalytic subunit type 3 | PIK3C3 | 5289 | Cytoplasm | 1.887 |
| phosphoinositide-3-kinase regulatory subunit 1 | PIK3R1 | 5295 | Cytoplasm | 1.557 |
| DNA polymerase kappa | POLK | 51,426 | Nucleus | 1.562 |
| cytochrome p450 oxidoreductase | POR | 5447 | Cytoplasm | −2.999 |
| peroxiredoxin 2 | PRDX2 | 7001 | Cytoplasm | 1.62 |
| perforin 1 | PRF1 | 5551 | Cytoplasm | 1.888 |
| protein kinase AMP-activated catalytic subunit alpha 1 | PRKAA1 | 5562 | Cytoplasm | −1.683 |
| presenilin 2 | PSEN2 | 5664 | Cytoplasm | −1.611 |
| prostaglandin E receptor 2 | PTGER2 | 5732 | Plasma Membrane | 1.877 |
| protein tyrosine phosphatase non-receptor type 11 | PTPN11 | 5781 | Cytoplasm | −1.714 |
| protein tyrosine phosphatase receptor type B | PTPRB | 5787 | Plasma Membrane | 1.544 |
| peroxidasin | PXDN | 7837 | Extracellular Space | 1.827 |
| RB transcriptional corepressor like 1 | RBL1 | 5933 | Nucleus | −1.614 |
| RAR related orphan receptor A | RORA | 6095 | Nucleus | −1.609 |
| RUNX family transcription factor 1 | RUNX1 | 861 | Nucleus | −1.563 |
| sphingosine-1-phosphate receptor 2 | S1PR2 | 9294 | Plasma Membrane | −1.619 |
| sarcoglycan beta | SGCB | 6443 | Plasma Membrane | −2.825 |
| SNF2 histone linker PHD RING helicase | SHPRH | 257,218 | Nucleus | −1.917 |
| solute carrier family 1 member 1 | SLC1A1 | 6505 | Plasma Membrane | −1.692 |
| solute carrier family 7 member 11 | SLC7A11 | 23,657 | Plasma Membrane | 1.719 |
| striated muscle enriched protein kinase | SPEG | 10,290 | Nucleus | 1.96 |
| secreted phosphoprotein 1 | SPP1 | 6696 | Extracellular Space | −1.573 |
| signal transducer and activator of transcription 6 | STAT6 | 6778 | Nucleus | −1.638 |
| stanniocalcin 1 | STC1 | 6781 | Extracellular Space | −1.546 |
| small VCP interacting protein | SVIP | 258,010 | Cytoplasm | −1.696 |
| transforming growth factor beta 2 | TGFB2 | 7042 | Extracellular Space | −1.584 |
| transforming growth factor beta receptor 2 | TGFBR2 | 7048 | Plasma Membrane | −1.801 |
| thrombospondin 1 | THBS1 | 7057 | Extracellular Space | −1.66 |
| TIA1 cytotoxic granule associated RNA binding protein | TIA1 | 7072 | Nucleus | −2.305 |
| toll like receptor 4 | TLR4 | 7099 | Plasma Membrane | −2.167 |
| tumor protein p53 | TP53 | 7157 | Nucleus | −1.518 |
| thioredoxin | TXN | 7295 | Cytoplasm | 1.692 |
| thioredoxin interacting protein | TXNIP | 10,628 | Cytoplasm | −2.163 |
| ubiquitination factor E4B | UBE4B | 10,277 | Cytoplasm | −1.591 |
| WASH complex subunit 1 | WASHC1 | 100,287,171 | Cytoplasm | −3.587 |
| ZFP36 ring finger protein | ZFP36 | 7538 | Nucleus | 1.942 |
a The Entrez gene ID is the unique integer identifier for humans; b normalized signal fold change in the 12 h-stored group to the corresponding signal of the control group.