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. 2023 Apr 28;12(5):826. doi: 10.3390/antibiotics12050826

Figure 5.

Figure 5

Shikonin inhibited gentamicin-induced renal apoptosis. The results were expressed as mean ± SD. CON, normal rats administered PBS i.p., SKN, the negative control group, which were orally treated with 25 mg/kg/day of shikonin dissolved in 1% DMSO for seven days, one h after the PBS injection, GTM, renal injury-induced rats by i.p. injection of 100 mg/kg/day gentamicin for seven days, VEH, renal injury-induced rats, which were orally treated with 1% DMSO in PBS (vehicle of shikonin), SKL, SKM, and SKH, renal injury-induced rats, which were orally treated with 6.25, 12.5, and 25 mg/kg/day of shikonin for seven days, respectively, one h after the gentamicin injection. * p < 0.05, ** p < 0.01, and *** p < 0.001 (vs. GTM group), + p < 0.05, ++ p < 0.01, and +++ p < 0.001 (vs. SKH group).