Table 1.
Effect of Paigen-type diet and osthole administration on echocardiographic parameters after 30 days follow-up.
| Parameter/ Group |
C | MS | MS+OT |
|---|---|---|---|
| IVS (mm) | 0.18 ± 0.019 | 0.205 ± 0.026 | 0.19 ± 0.012 |
| LVEDd (mm) | 4.96 ± 0.44 | 4.88 ± 0.39 | 4.62 ± 0.57 |
| LVEDs (mm) | 2.33 ± 0.53 | 2.06 ± 0.37 | 2.02 ± 0.43 |
| LVPW (mm) | 0.17 ± 0.019 | 0.19 ± 0.019 | 0.18 ± 0.016 |
| EF (%) | 81.4 ± 5.62 | 84.4 ± 6.1 | 83.3 ± 6.5 |
| FS (%) | 53.4 ± 7.36 | 57.7 ± 7.3 | 56.3 ± 8.5 |
| HR (bpm) | 424.5 ± 34.72 | 378.9 ± 51.4 | 412.5 ± 32.1 |
| Body weight (g) | 292.5 ± 5.82 | 336.4 ± 14.30 | 314 ± 15.9 |
| Heart weight (HW, g) | 1.05 ± 0.07 | 1.37 ± 0.05 a | 1.26 ± 0.03 b |
| Lung weight (LW, g) | 1.90 ± 0.13 | 3.83 ± 0.39 a | 2.91 ± 0.20 b |
| Tibial length (TL, cm) | 3.92 ± 0.14 | 4.20 ± 0.20 | 3.84 ± 0.83 |
| HW/TL (g/cm) | 0.27 ± 0.02 | 0.33 ± 0.02 | 0.35 ± 0.11 |
| LW/TL (g/cm) | 0.49 ± 0.04 | 0.91 ± 0.10 a | 0.82 ± 0.32 a |
| HW/BW (g/kg) | 3.52 ± 0.20 | 4.56 ± 0.24 a | 4.38 ± 0.29 a |
| LW/BW (g/kg) | 6.38 ± 0.55 | 12.72 ± 1.38 a | 10.16 ± 1.26 a,b |
| Functional parameters | (n = 7) | (n = 8) | (n = 7) |
Data are the mean ± SD of at least 6 different animals in each experimental group. a p ≤ 0.05 vs. C; b p ≤ 0.05 vs. MS. I.V.S.: interventricular septum; LVEDd: LV dimension at the end of diastole; LVEDs: LV dimension at the end of systole; LVPW: LV dimension posterior wall, EF: ejection fraction; FS: fractional shortening; HR: heart rate; bpm; beats per minute.