Table 1.

Methods and properties of lipid-based system.

Materials	Polyphenols	Methods and Functionalization	EE * and LC **	Particle Size	Ref.
Liposome	Resveratrol	PEGylation TF moiety	EE ~75%	211.2 nm	[55]
		Peptide liposome	EE > 90%	140 nm	[56]
	Curcumin	Co delivery with gefitinib PEGylation	EE > 80%	110–130 nm	[57]
Phytosome	Genistein	With MCT or LCT Solvent evaporation method	EE > 95%	150–300 nm	[61]
	Thymoquinone	Soy-phospholipid	No data	45.6 nm	[62]
	Curcumin	PEGylation Folate modification	LC 24.3%	185.3 nm	[63]
	Moringa oleifera leaf polyphenols	Soy-phosphatidylcholine Thin-layer hydration method	EE 90.23%	296 nm	[64]
Nanostructured lipid particle	Curcumin	Cinnamon oil, Tween 80 PEG 200, Absorption enhancer	No data	106 nm	[66]
	Cornus mas extract (CME)	Cubosome Glyceryl monooleate Poloxamer® 407 Eudragit® S100	EE 95.14% LC 9.51%	22.7 nm	[67]
	EGCG	Arginyl-glycyl-aspartic acid (RGD) modification	EE 80% LC 75%	85 nm	[68]
	Apigenin	Hyaluronic acid modification Co-treatment with docetaxel	EE 70% LC 3.5%	88 nm	[69]

* EE: Encapsulation efficiency % (loaded polyphenol amount/initial polyphenol amount × 100); ** LC: Loading capacity % (Loaded polyphenol weight/polyphenol-loaded particle weight × 100).